Susan Meakin

Genetics & Development Dr. Susan Meakin
Associate Scientist
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Affiliations

Associate Scientist, Division of Genetics & Development, Children's Health Research Institute
Scientist, Molecular Brain Research Group, The Robarts Research Institute
Professor, Department of Biochemistry & Neuroscience, Schulich School of Medicine & Dentistry, Western University

Research

Current Research Activity

Dr. Meakin's research centers around the signalling properties of a family of cell surface receptors, termed Trks, which are expressed exclusively in the developing and mature nervous systems.  Trk receptors regulate the development of multiple types of neurons in the brain as well as the process of learning and memory.

All of the research in Dr. Meakin's lab utlize a variety of molecular, genetic and cell biology approaches including primary cell culture, confocal microscopy and animal models.  Where appriate, we also seek collaborations with local and international colleagues.

Awards & Grants

Grants

Funding in support of "The Role of FRS3 in Regulating Cortical Neuron Development" - Awarded by Lawson Health Research Institute (LHRI) Internal Research Grant

Funding in support of "The Role of FRS3 during Cortical Development" - Awarded by Western University

Funding in support of "Mechanism of Trk Dependent Cell Death in Human Brain Tumours" - Awarded by Cancer Research Society Inc.

Funding in support of "Structure, dynamics and contingency in signaling regulatory networks" - Awarded by Canadian Institutes of Health Research (CIHR)

Recent Publications

Publications

Ras Guanine nucleotide Releasing Factor 1 (RasGrf1) enhancement of Trk Receptor mediated Neurite Outgrowth requires Activation of both H-Ras and Rac
Talebian A, Robinson-Brookes KN, MacDonald JIS, Meakin SO
J Mol Neurosci. 2013; 49(1):38-51

Nesca, a Novel Neuronal Adapter Protein, Links the Molecular Motor Kinesin with the Pre-Synaptic Membrane Protein, Syntaxin-1, in Hippocampal Neurons
MacDonald JIS, Dietrich A, Gamble S, Hryciw T, Grant RI, Meakin SO
J Neurochemistry. 2012; 121:861-880

Role and expression of FRS2 and FRS3 in prostate cancer
Valencia T, Joseph A, Kachroo N, Darby S, Meakin SO, Gnanapragasam VJ
BMC Cancer. 2011; 11:484

In Vivo Detection of MRI-PARACEST Agents in Mouse Brain Tumors at 9.4 Tesla
Li A, Suchy M, Li C, Gati JS, Meakin SO, Hudson RHE, Menon RS, Bartha R
Magnetic Resonance in Medicine. 2011 July; 66(1):67-72

Contact

Contact

Phone: (519) 931-2777, x24304
Fax: (519) 931-5222
Email: smeakin [at] robarts [dot] ca
Website: http://www.robarts.ca/smeakin/

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