Scientist, Division of Children's Health & Therapeutics, Children's Health Research Institute
Assistant Professor, Department of Physiology & Pharmacology, Schulich School of Medicine & Dentistry, Western University
Reseach in the Tirona Lab focuses on molecular determinants of drug response and toxicity. In particular, studies are performed to characterize and understand the factors that govern interindividual differences in drug pharmacokinetics. The laboratory is especially interested in transport proteins and their impact on tissue drug distribution and elimination. Moreover, the role of nuclear receptors in determining the expression of drug metabolizing enzymes and transporters is also an area of interest. A variety of biochemical, molecular biological and genetic methods are employed in cellular and animal models together with studies in humans. Currently, the laboratory is investigating the role of drug transporters in the skeletal muscle toxicity of the cholesterol-lowering drugs. In addition, we are studying the interplay between transporters and metabolizing enzymes with respect to quantitative in vitro to in vivo prediction of drug pharmacokinetics.
Phone: (519) 685-8500, ext 32102
Fax: (519) 663-3444
Email: rtirona [at] uwo [dot] ca
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