Rodney P DeKoter

Genetics & Development Dr. Rodney P DeKoter
Scientist
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Affiliations

Scientist, Division of Genetics & Development, Children’s Health Research Institute
Associate Professor, Department of Microbiology & Immunology, Schulich School of Medicine & Dentistry, 
Western University
Affiliate Member, Division of Experimental Oncology, Western University

How my research helps children

The goal of our research is to identify genetic causes of diseases affecting the immune system, including primary immunodeficiency and leukemia. These diseases are rare but devastating since there are few treatment options. We are working hard to develop new cutting-edge therapies to fight these diseases.

Research

Research Team

Dr. DeKoter’s research team includes two graduate students, a postdoctoral fellow and a research technician. Our laboratory takes on undergraduate students and summer students on a regular basis.

Future Research Plans

The goal of Dr. DeKoter’s research is to identify genetic causes of diseases affecting the immune system, including primary immunodeficiency and leukemia.  These diseases are rare but devastating since there are few treatment options.  Members of the lab are working to determine how mutation of genes encoding transcription factors contributes to B cell acute lymphoblastic leukemia and acute myeloid leukemia. His research team is working hard to develop new cutting-edge therapies to fight these diseases.

Awards & Grants

Awards & Grants

Funding in support of "Pivotal role of Spi-B in B cell leukemia and lymphoma" - Awarded by Canadian Institutes of Health Research

Funding in support of "Function of PU.1 and Spi-B in B cell acute lymphoblastic leukemia" – Awarded by Leukemia & Lymphoma Society of Canada

Funding in support of “Functions of related Ets transcription factors in B cells” – Canadian Institutes of Health Research (CIHR)

Funding in support of “Graded regulation of gene expression by PU.1” – Awarded by National Sciences and Engineering Research Council (NSERC)

Recent Publications

Publications

PU.1 opposes IL-7-dependent proliferation of developing B cells with involvement of the direct target gene Bruton tyrosine kinase
Christie DA, Xu Li X, Turkistany SA, Solomon LA, Li SKH, Welch I, Bell GI, Hess DA, DeKoter RP
The Journal of Immunology. 2015; 194:595-605

PU.1 promotes cell cycle exit in the murine myeloid lineage associated with down-regulation of E2F1
Ziliotto R, Gruca MR, Podder S, Noel G, Ogle CK, Hess DA, DeKoter RP
Experimental Hematology. 2014; 42:204-217

Transcriptional regulation of Peptidylarginine Deiminase Type IV in human myeloid cells
Abbas AK, Le K, Pimmett VL, Bell DA, Cairns E, DeKoter RP
Gene. 2014; 533:123-131

Regulation of B cell linker protein transcription by PU.1 and Spi-B in murine B cell acute lymphoblastic leukemia
Xu LS, Sokalski KM, Hotke K, Christie DA, Zarnett O, Piskorz J, Thillainadesan G, Torchia J, DeKoter RP
J Immunology. 2012;189:3347-3354

Peyer’s patch M cells derived from Lgr5+ stem cells require Spi-B and are induced by RankL in cultured ‘miniguts’
De Lau W, Kujala P, Schneeberger K, Middendorp S, Li VSW, Barker N, Martens A, Hofhuis F, DeKoter RP, Peter PJ, Nieuwenhuis E, Clevers H
Molecular and Cellular Biology. 2012;18:3639-3647

Optimization and application of a flow cytometric PU.1 assay for murine immune cells
Noel G, DeKoter RP, Wang Q, Hexley P, Ogle CK
J Immunological Methods. 2012;382:81-92

Master transcription factors determine cell-type-specific responses to TGF- signaling.
Mullen AC, Newman JJ, Orlando DA, Kumar RM, Bilodeau S, Reddy J, DeKoter R, Young RA
Cell. 2011;147:565-576

Deletion of genes encoding PU.1 and Spi-B in B cells impairs differentiation and induces pre-B cell acute lymphoblastic leukemia
Sokalski KM, Welch I, Cadieux-Pitre HA, Li SH, Gruca MR, DeKoter RP
Blood. 2011;118:2801-2808

Additional publications

Contact

Contact

Phone: (519) 661-2084
Fax: (519) 661-3499
Email: rdekoter [at] uwo [dot] ca
Web: http://publish.uwo.ca/~rdekoter

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