Madhulika Gupta

Maternal, Fetal & Newborn Health Dr. Madhulika Gupta
Scientist
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Affiliations

Scientist, Division of Maternal, Fetal & Newborn Health, Children’s Health Research Institute
Assistant Professor, Department of Paediatrics and Biochemistry, Schulich School of Medicine & Dentistry, Western University

How my research helps children

With my diverse industrial experience, my research career at Western University began studying the pathophysiology of fetal growth restriction (FGR) and simultaneously looking into the biomarkers for this disease. FGR occurs mainly due to various degrees of fetal hypoxia and decreased nutrient availability. In the past 3 to 4 years I have transitioned my independent research program to identifying mechanisms that diminish growth in response to cellular stress conditions and affect fetal growth during in utero development.
FGR newborns have higher rates of infant mortality and are susceptible to poor cardiovascular health and metabolic diseases, later in life, My work would help clinicians in early prognostication and better management of the pathological (FGR) pregnancies.

Research

Current Research Activities

Recently, my laboratory has published several manuscripts in leading journals in the area of endocrinology and clinical proteomics. The novel findings from four of my recent publications has been curated into PhosphoSitePlus, an open resource for the research community that is supported by the NIH for medical research.

Research Team

My lab currently consists of one graduate student and a research assistant, who recently completed MSc in my lab. Both graduate students have received awards and recognitions for their work. I have in addition trained a number of undergraduate students and there are currently two Summer students (2010). One of my trainees will pursue graduate program in my lab in the fall of 2010.

Future Research Plans

I have recently established close interactions with scientists at the Center for Pregnancy and Newborn Research, San Antonio, University of Texas medical center USA. I am looking forward to an active collaboration to investigate “the molecular mechanisms linking placental nutrient sensing and fetal programming”.

Awards & Grants

Awards & Grants

Funding in support of "Molecular mechanisms in regulation of IGFBP-1 phosphorylation"  – Awarded by NSERC Discovery Grant

Funding in support of "The role of IGFBP-1 phosphorylation in the regulation of IGF-1 bioactivity in pre- and post-natal growth in the SGA preterm infant – Awarded by Children's Health Research Institute (CHRI) & Department of Paediatrics Translational Research Grant Fund (TRGF)

Funding in support of "Regulation of IGFBP-1 phosphorylation in intrauterine growth restriction" – Awarded by Lawson Health Research Institute (LHRI) Internal Research Grant Fund (IRGF)

Funding in support of "An in vitro study to eludicate mechanism regulating IGFBP-1 phosphorylation in FGR" – Awarded by Children's Health Research Institute (CHRI) Internal Research Grant Fund (IRGF)

Funding in support of "Molecular mechanisms linking placental nutrient sensing and fetal programming" – Awarded by NIH R21

Funding in support of "Regulation of fetal growth" – Awarded by Canadian Institutes of Health Research (CIHR) (co-investigator)

Funding in support of "Regulation of IGFBP-1 Phosphyoylation in IUGR" – Awarded by Department of Paediatrics Research Committee, Schulich Medicine & Dentistry

Funding in support of "Molecular mechanism in regulation of IGFBP-1 phosphorylation in reduced oxygen and nutrient availability" – Awarded by Children's Health Research Institute (CHRI) Internal Research Grant Foundation (IRGF)

Funding in support of "Role of phosphorylation of IGFBP-1 in modulation of IGF action: A functional phospho-proteomics approach to study fetal development" – Awarded by Natural Sciences and Engineering Research Council of Canada (NSERC)

Funding in support of "Regulation of fetal growth" – Awarded by Canadian Institutes of Health Research (CIHR)

Funding in support of "Proteomics of FGR: An analysis of maternal plasma" – Awarded by Human Growth Foundation, NY USA

Funding in support of "Proteomic analysis of phosphoisoforms of IGFBP-1 involved in the pathophysiology of IUGR" – Awarded by Children’s Health Research Institute (CHRI)

Recent Publications

Publications

Circulating levels of liver-secreted angiogenic and haemostatic plasma proteins related to oxygen level in the fetus
Seferovic MD, Chen S, Pinto D, Gupta MB
J Proteome Res. 2011; 10:1495-1504

Altered liver secretion of vascular regulatory proteins in hypoxic pregnancies stimulate angiogenesis in vitro
Seferovic MD, Chen S, Pinto DM, Gupta MB
J Proteome Res. 2011 Apr 1;10(4):1495-504.

Insulin-like growth factor binding protein-6 (IGFBP-6) interacts with DNA-end binding protein Ku80 to regulate cell fate
Iosef C, Vilk G, Gkourasas T, Lee KJ, Chen BP, Fu P, Bach LA, Lajoie G, Gupta MB, Li SS, Han VK
Cell Signal. 2010 Jul;22(7):1033-43.

Site-specific IGFBP-1 hyper-phosphorylation in fetal growth restriction: clinical and functional relevance
Abu Shehab M, Khosravi J, Han VK, Shilton BH, Gupta MB
J Proteome Res. 2010 Apr 5;9(4):1873-81.

Site specific phosphorylation of insulin-like growth factor binding protein-1 (IGFBP-1) for evaluating clinical relevancy in fetal growth restriction
Abu Shehab M, Inoue S, Han VK, Gupta MB
J Proteome Res. 2009 Nov;8(11):5325-35.

Functional and complementary phosphorylation state attributes of human insulin-like growth factor-binding protein-1 (IGFBP-1) isoforms resolved by free flow electrophoresis
Nissum M, Abu Shehab M, Sukop U, Khosravi JM, Wildgruber R, Eckerskorn C, Han VK, Gupta MB
Mol Cell Proteomics. 2009 Jun;8(6):1424-35

Hypoxia and leucine deprivation induce human insulin-like growth factor binding protein-1 hyperphosphorylation and increase its biological activity
Seferovic MD, Ali R, Kamei H, Liu S, Khosravi JM, Nazarian S, Han VK, Duan C, Gupta MB.
Endocrinology. 2009 Jan;150(1):220-31.

Quantitative 2-D gel electrophoresis-based expression proteomics of albumin and IgG immunodepleted plasma
Seferovic MD, Krughkov V, Pinto D, Han VK, Gupta MB
J Chromatogr B Analyt Technol Biomed Life Sci. 2008 Apr 1;865(1-2):147-52

Cloning, expression, purification and functional characterization of recombinant human PSP94
Garde S, Fraser JE, Nematpoor N, Pollex R, Morin C, Forté A, Rabbani S, Panchal C, Gupta MB
Protein Expr Purif. 2007 Aug;54(2):193-203.

Haptoglobin α2 in maternal plasma from pregnancies with fetal growth restriction
Gupta M.B, Seferovic M., Suya Li, S., Gratton R., Lajoie G., and Han V.
Clinical Proteomics 2, 2006 (3-4), 169-184

Additional publications

Contact

Contact

Phone: (519) 685-8500, x55099
Fax: (519) 685-8186
Email: mbgupta [at] uwo [dot] ca
Website: https://www.schulich.uwo.ca/paediatrics/faculty/madhulika-gupta

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