Laudelino Lopes

Maternal, Fetal & Newborn Health Dr. Laudelino Lopes
Scientist
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Affiliations

Scientist, Division of Maternal, Fetal & Newborn Health Children’s Health Research Institute
Associate Professor, Department of Obstetrics and Gynaecology, Schulich School of Medicine & Dentistry, Western University
Associate Scientist, Lawson Health Research Institute
Division Head, Maternal Fetal Medicine Division, Western University

How my research helps children

Basic Research: Stem Cells
Infusion of stem cells from umbilical cord blood can improve the quality of life for children with cerebral palsy.  Umbilical cord blood is rich in stem cells.  Cerebral palsy, caused by a brain injury or lack of oxygen in the brain, during pregnancy, before birth or during the first few years of life, can impair movement, learning, hearing, vision and cognitive skills.  Two to three children in 1,000 are affected by it, according to the Centers for Disease Control.  Animal studies indicate that infused stem cells help injured brain cells recover and replace brain cells that have died.  Autologous stem cell transplantation, in which the transplant recipient is also the donor, is the safest form of stem cell transplantation because it carries virtually no threat of immune system rejection.  I believe that stem cell research holds extraordinary potential for the development of new therapies for the children we treat and for the countless others like them throughout the world.

Clinical Research: First Trimester Ultrasound – A New Horizon
Scans in early pregnancy are usually performed in the first trimester around 12 weeks.  You may have an earlier scan, if you are experiencing pain or bleeding for example or unsure of LMP dates.  It is recommended that all pregnant women have a scan in the first trimester, to establish the date when the baby is due, check the number of babies, also the position of the placenta.  First trimester ultrasonic scans may show 'soft' markers for chromosomal abnormalities, such as the absence of fetal nasal bone or an increased fetal nuchal translucency (back of the neck) to enable detection of Down syndrome fetuses.

Looking Forward….
Basic:  Our Research Department established a stem cell program whose sole mission is to explore, understand and translate the promise of stem cells into clinical therapies and treatments

Clinical: The Ob/Gyn Department – Western University became a referral center for Genetic/Ultrasound Screening and High Risk pregnancy.

Academic Achievements

Associate Professor - Western University - Canada - Full-time Faculty member.  Scientist at Children's Health Research Institute (CHRI), Canada.  Associate Scientist at Lawson Health Research Institute (LHRI), Canada - since November 2009.

Chair of the Department of Obstetrics & Gynaecology and Chief of the Division of Maternal Fetal Medicine named PERINATAL LARANJERIAS since February 12, 1993 until October 2009, as a full-time Associate Professor - offering 47 beds for OB/GYN, 3 beds for Maternal Intensive Care and 35 beds for Neonatal (NICU).  Over 5,000 deliveries are currently performed per year.

Perinatal Laranjerias is a benchmark in specialized Perinatal care.  The Departments which Dr. Lopes coordinates are considered a regional, state, national and international reference in Maternal Fetal Medicine.

In the Division of Maternal Fetal Medicine and at the Department of OB/GYN, around 35,000 ultrasounds are performed per year, along with 300 invasive procedures in Fetal Medicine.  Moreover, we have a significant clinic of minimally invasive gynecological surgery (MIGS), as well as 24-hour emergency facilities' for OB/GYN, adding up to 800 non-obstetrical procedures annually.  Hold the position of Division Head of Obstetrics & Gynaecology, Maternal Fetal Medicine and Ultrasound Departments.

A new unit called Perinatal Barra was opened in january 2009, and Dr. Lopes was invited for the position of Chief Director of the OB/GYN and Maternal Fetal Medicine Departments for all units.  (Supervising 75 assistant physicians in both units.)

The working schedule included 20 hours in clinical and surgical practice (imaging, surgeries and outpatients) and 20 hours dedicated to managing, organization and coordination.  My main responsibilities involve academic coordination, teaching and continuing education, organization of the CME Centre, participation in national and international meetings and tutoring of Master and Doctoral thesis and dissertation.  In the past years, I tutored six Master and two PhD students, all of whom have already concluded their academic programs using data from our own institution.

Research

Current Research Activities

Stem Cell
Human umbilical cord blood mononuclear cells (HUCB) have been shown to have a therapeutic role in different models of central nervous system (CNS) damage, including stroke.  We evaluated the possible therapeutic potential of human umbilical cord blood mononuclear cells (HUCB) in P7 rats submitted to the Rice-Vannucci model of neonatal hypoxic-ischemic (HI) brain damage.

Our results demonstrated that intraperitoneal transplantation of HUCB, 3 hours after the HI insult, resulted in better performance in two developmental sensor motor reflexes, in the first week after the injury.  We also showed a neuroprotective effect in the striatum, and a decrease in the number of activated microglial cells in the cerebral cortex of treated animals.  We suggest that HUCB transplantation might rescue striatal neurons from cell death after a neonatal HI injury, resulting in better functional recovery.

‘Cell Theraphy Through Transplant of Stem Cells from the Umbilical Cord in Newborns with Serious Neurological Complications’, Fundação Carols Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro FAPERJ – Regenerative Medicine, Principle Investigator

CHIPS
‘CHIPS (MIRU – Toronto)’, Canadian Institutes of Health Research (CIHR)-Co-applicant

Twin Birth Study
‘Twin Birth Study: A Multicentre Controlled Trial Comparing Planned Vaginal Birth for Twins at 32-38 Weeks Gestation’, Canadian Institutes of Health Research (CIHR) – Randomized Controlled Trials, Co-applicant

Laser and Fetal Surgery
‘Laser and Fetal Surgery’ Fundação Carols Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro FAPERJ – Innovation in OB/GYN – Rio de Janeiro – Brazil, Co-applicant

Future Research Plans

Clinical Research  - The 11-13 weeks scan
Create conditions at the Maternal Fetal Medicine Division (Department of Obstetrics and Gynecology – Western University) to cover all the important aspects of first-trimester screening for chromosomal abnormalities, the diagnosis of major fetal defects and screening for preeclampsia, based on the Fetal Medicine Foundation (FMF) Society model.

Make sure that all consultants and sonographers will obtain the FMF Certificates of competence in the measurement of nuchal translucency, assessment of the nasal bone, measurement of the facial angle, assessment of ductus venosus flow, assessment of tricuspid flow and measurement of uterine artery Doppler flow.

Basic Science  Research  
‘Insulin-Like Growth Factor System in Mesencymal Stem Cell Development’, Canadian Institutes of Health Research (CIHR) – Operating Grant (Requested), Co-applicant

Awards & Grants

Distinctions/Awards/Credentials (2005-2012)

2011 - Consultant of the Year Award - Citywide Department of Family Medicine - Western University, Canada
2011 - Top Medical Quality and Social Responsibility Award - Academia Brasileira de Honrarias ao Merito, Obstetrics, Sao Paulo, Brazil
2010 - Best Poster Award - The Fetal Medicine Foundation - United Kingdom - 9th World Congress in Fetal Medicine and the Eurofetus Meeting, Rhodes, Greece
2009 - Top Medical Quality - Distinction - Brazilian Medical Academy, Brazil
2008 - Latin Am Quality Award - Distinction - Latin American Academy of Art (ALA), Brazil
2008 - Dipl Prof Merit Med Sc - Credential - Latin American Academy of Art (ALA), Brazil
2008 - 1st Award Jorge Rezende - Research Award - Federal University of Rio de Janeiro, Brazil
2008 - Award Med Analysis - Distinction - Brazilian Medical Association, Brazil
2007 - Top Medical Quality - Distinction - Brazilian Medical Academy, Brazil
2007 - Top Quality Latin Am OB/GYN - Distinction - Brazilian Parliamentary Order, Brazil
2006 - MD Prof Merits in Research - Research Award - Brazilian Medical Academy, Brazil
2006 - Top Entrepreneur Montreal - Distinction - Brazilian Medical Academy, Brazil

Grants Held (2005-2012)

Funding in support of Extremely low gestational age (ELGA): Short-term neonatal morbidity and mortality  – Awarded by Western University Academic Enrichment Fund (AEF) – 2013-2014

Funding in support of Placental Mesenchymal Stem Cells in Regenerative Therapy – Awarded by Canadian Institute of Health Research (CIHR), Co-applicant, 2011-2016

Funding in support of Evaluation of a comprehensive first trimester pregnancy risk assessment - a pilot study – Awarded by Western University Academic Enrichment Fund (AEF) – 2011-2012

Funding in support of CHIPS (MIRU – Toronto) – Awarded by Canadian Institutes of Health Research (CIHR) – Co-applicant – 2009-2015

Funding in support of Cell Therapy Through Transplant of Stem Cells from the Umbilical Cord in Newborns with Serious Neurological Complications – Awarded by Fundação Carols Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro FAPERJ – Regenerative Medicine – Principle Investigator – 2005-2012

Funding in support of Twin Birth Study: A Multicentre Controlled Trial Comparing Planned Vaginal Birth for Twins at 32-38 Weeks Gestation – Awarded by  Canadian Institutes of Health Research –Randomized Controlled Trials – Co-applicant – 2003-2011

Funding in support of Laser and Fetal Surgery – Awarded by Fundação Carols Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro FAPERJ – Innovation in OB/GYN – Co-applicant – 2006-2011

Funding in support of Multiple Courses of Antenatal Corticoseriods for Preterm Birth – Awarded by Canadian Institutes of Health Research (CIHR) – Randomized Controlled Trials – Co-applicant – 2006-2010

Recent Publications

Publications

2006-2013
A Randomized Trial of Planned Cesarean or Vaginal Delivery for Twin Pregnancy
Barrett JF, Hannah ME, Hutton EK, Willan AR, Allen AC, Armson BA, Gafni A, Joseph KS, Mason D, Ohlsson A, Ross S, Sanchez JJ, Asztalos EV, the Twin Birth Study Collaborative Group (Lopes LM)
The New England J of Medicine. 2013 Oct 3; 369(14):1295-1305

Prevention of Preeclampsia
Moura SBM, Lopes LM, Murthi P, daSilva CF
J Pregnancy. 2012:435090; pp 1-9. doi:10.1155/2012/435090

Normal range for fetal urine production rate customized biometry
Peixoto-Filho FM, deSa RA, Velards LG, deCastro Mocarzel C, Lopes LM, Ville Y
Arch Gyneco Obstet. 2012 Aug 17

Magnesium sulphate for fetal neuroprotection
Costa FS, Lopes LM, Brennecke S
Rev Bras Ginecol Obstet [Online]. 2011 June;33(6):265-270

SNAPPE-II application newborns with very low birth weight: evaluation of adverse outcomes in severe placental dysfunction
Carvalho PRN, Moreira MEL, Sá RAM, Lopes LM
J Perinat Med. 2011 May;39:343-347

Normal range for fetal urine production rate by 3-D ultrasound in Brazilian population
Peixoto-Filho FM, de Sa RA, Velarde LG, Lopes LM, Ville Y
Arch Gynecol Obstet. 2011 Mar;382(3):497-500

Human cord blood transplantation in a neonatal rat model of hypoxic-ischemic brain damage: functional outcome related to neuroprotection in the striatum
Pimentel-Coelho PM, Magalhães ES, Lopes LM, deAzevedo LC, Santiago MF, Mendez-Otero R
Stem Cells Dev. 2010 Mar;19(3):351-358

Median levels of free beta-hCG and PAPP-A in the first trimester screening for Down syndrome in a Brazilian population from a private center in Rio de Janiero
Lopes LM, Peixoto FF, Sa RM, Fonseca AA, Neto EV
Ultrasound in Obstet Gynecol. 2009 34:222

First-trimester combined screening for aneuploidy in a Brazilian population from a private center in Rio de Janeiro: a preliminary study
Lopes LM, Peixoto FF, Sa RM, Fonseca AA, Neto EV
Ultrasound in Obstet Gynecol. 2009 34:218

Twin-to-Twin Transfusion Syndrome - Brazilian Perinatal Center Case Review
Lopes LM, De Sá RAM, Jorge De Almeida P
J Obstetrics and Gynecology of Canada. 2009 31(5):S45

Human cord blood transplantation in a neonatal rat model of hypoxic-ischemic brain damage: functional outcome related to neuroprotection in the striatum
Pimentel-Coelho PM, Magalhães ES, Lopes LM, De Azevedo LC, Santiago MF, Mendez-Otero R
Stem Cells Dev. 2009 Mar 18

Doppler and birth-weight Z score: predictors for adverse neonatal outcome in severe fetal compromise
Silva FC, Sá RAM, Carvalho PRN, Lopes LM
Cardiovascular Ultrasound. 2007 Mar 20; 5:15

Predicting adverse neonatal outcome in severe fetal compromise: A pivotal role for estimated fetal weight Z scores
Sá RAM, Salomon LJ, Carvalho PR, Lopes LM, Ville Y
Prenat Diagn. 2007; 27(12):1129-1132

Three-dimensional ultrasound fetal urinary bladder volume measurement: reliability of rotational (VOCAL®) technique using different steps of rotation
Filho P, Maia F, Sá RAM, Lopes LM, Velarde LGC, Marchiori E, Ville Y
Archives of Gynaecology and Obstetrics. 2007; 276(4):345-349

Three-dimensional ultrasound fetal urinary bladder volume measurement: reliability of rotational (VOCAL®) technique using different steps of rotation
Filho P, Maia F, Sá RAM, Lopes LM, Velarde LGC, Marchiori E, Ville Y
Ultrasound in Obstetrics & Gynaecology. 2007; 30:0378-378

Reliability of three-dimensional ultrasound fetal urinary bladder volume measurement
Filho P, Maia F, Sá RAM, Lopes LM, Velarde LGC, Marchiori E, Ville Y
Ultrasound in Obstetrics & Gynecology. 2007; 30:0551-551

Predicting adverse neonatal outcome in severe fetal compromise: a pivotal role for estimated fetal weight Z-score
Sá RAM, Salomon LJ, Carvalho PRN, Lopes LM, Ville Y
Ultrasound in Obstetrics & Gynecology. 2007; 30:0583-583

Videohysteroscopy resection of myoma: the importance of ultrasound in the per-operatory
Valle ER, Araujo R, Sá RAM, Lopes LM
Ultrasound in Obstetrics & Gynecology. 2007; 30:0612-612

Adverse neonatal outcome in severe compromised premature fetuses - the pivotal role of ductus venosus velocimetry
Cosmo YC, Murta CGV, Sá RAM, Carvalho PRN, Lopes LM
Ultrasound in Obstetrics & Gynecology. 2007; 30:0643-643

Centrell's Pentolgy in Twins: Prenatal Diagnosis
Sá RAM, de Souza Filho GP, Lopes LM, Faleiro EC, Junior JA
Twin Research and Human Genetics. 2006; 9:597-599

Stem Cells - Parte II
Lopes LM
Femina (Brazilian Federation of the Societies of Gynecology and Obstetrics). 2006; 34:379-380

Stem Cells - Parte I
Lopes LM
Femina (Brazilian Federation of the Societies of Gynecology and Obstetrics). 2006; 34:311-313

Predicting adverse neonatal outcome in fetuses with severe placental insufficiency: a pivotal role for birth weight Z-scores
Sá RAM, Salomon LJ, Lopes LM, Ville Y
Ultrasound in Obstetrics & Gynecology. 2006; 28:492-492

Book Chapters (2006-2013)

Doppler en Embarazo Multiple con enfasis en el Sindrome de Transfusion Feto-Fetal. Sá RAM, Lopes LM, Ville Y. In: Doppler Materno-Fetal Coleccion de Medicina Fetal y Perinatal (Eds. Mario Palermo, Ana Expinesa). 2011; Ch 10, 141-154

Polidramnia Oligodramnia. Lopes LM, Peixoto-Filho FM, da Silva. In: Obstetricia 11th ed Guanabara Koogan - Rio de Janeiro (Eds. Carols Antonio Barbosa Monetegro, Jorge Rezende Filho). 2010. Ch 33, 423-431

Reliability of Three-Dimensional Ultrasound Measurement of Hourly Fetal Urine Production Rate. Sá RAM, Peixoto-Filho FM, Mocarzel CC, Lopes LM, Velards LGC, Grupo Periatla. In: Handbook of Prenatal Diagnosis: Methods, Issues and Health Impacts. Nova Biomedical (eds. Elian Perira and Juliano Soria). 2010 Nova Science Publisher, Inc. 2010; Ch XIX, 302-307

Perspective of the use of Umbilical cord stem cells. Lopes LM, Santos MBP, Sá RAM, Santos RR. In: Perinatologia Básica. 3rd ed Rio de Janeiro (Editora Guanabara Koogan SA). 2006; v. 1, 28-34

Perspective of the use of Umbilical cord stem cells in Regenerative Medicine. Lopes LM, Santos MBP, Sá RAM. In: PROAGO - Programa de atualizacao em Ginecologia e Obstetricia (ed. Porto Alegre / RS: Artmed Panamericana Editora Ltda). 2006; 97-127

Articles, published in magazines (2006-2013)

Top Entrepreneur
Lopes LM
Top of Business Magazine. Porto Alegre - RS, 9-9, 2007

Safe baby expectancy
Lopes LM, Sá RAM
Revista de Domingo Jornal do Brazil. Rio de Janeiro, 46-47, 2006

Additional publications

Contact

Contact

Phone: (519) 685-8500, x61026
Fax: (519) 646-6213
Email: laudelino [dot] lopes [at] lhsc [dot] on [dot] ca