Guido Filler

Children's Health & Therapeutics Dr. Guido Filler
Scientist
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Affiliations

Scientist, Division of Children’s Health and Therapeutics, Children's Health Research Institute
Professor, Departments of Paediatrics, Pathology & Laboratory Medicine, and Medicine, Schulich School of Medicine & Dentistry, Western University
Section Head, Paediatric Nephrology, Department of Paediatrics, Western University

How my research helps children

My work addresses various aspects of the management of children with kidney diseases and high blood pressure. One important area pertains to the measurement of kidney function. Ninety one scientific manuscripts have been published on measuring the ability of the kidney to clear toxins without involving a nuclear medicine scan, using low molecular weight proteins, especially Cystatin C. Measurement of this marker replaces the need for nuclear medicine scans and also serves as a better marker to monitor dialysis. Another important area is related to the changes of drug disposition and drug clearance related to the developing body of a child. Especially anti-rejection drugs and anti-viral drugs have been studied. This allows for an age appropriate and safe dosing of drugs in children across all ages.

Research

Current Research Activities

In collaboration with Dr. Robert Lindsay, Dr. William Clark and Dr. Shi-Han S. Huang, the use of Cystatin C as a marker of dialysis adequacy both in children and adults is being tested. We are also testing this marker in children with cystic fibrosis. This research project is generously supported by the Canadian Cystic Fibrosis Foundation. Together with Dr. Ajay Sharma, Dr. Filler studies hypertension in children. There are also several ongoing studies on slowing chronic kidney disease in children before and after kidney transplantation. Dr. Filler is also very involved in the departmental healthy weight study.  Recently, through collaboration with the Paediatric Chairs of Canada, where Dr. Filler, together with the chair from Laval, is responsible for the manpower survey and human resource database, several research projects related to the supply of paediatricians and paediatric subspecialists have also surfaced and have led to the submission of a CIHR team grant.  The research team consists of a consortium including Stats Canada, CAPER, CIHI and others.  The aim of the research is to link health outcomes to access to paediatricians to inform the government about adequate human resource allocation in the entire country.

Research Team

There is close collaboration with Dr. Ajay Sharma (Associate Professor of Paediatrics), Dr. Abeer Yasin, PhD (applied mathematics), Tracy Robinson (coordinator of the healthy weight study), and multiple medical students and residents. Since Dr. Filler’s arrival in Canada, he brought 40 medical students and over 20 residents and fellows to publications in peer-reviewed journals (range 1-5).

Future Research Plans

To enhance the work on the measurement of renal function. To augment the work on slowing progression of chronic kidney disease through better treatment of hypertension. To continue with the clinical pharmacology work to better understand the developmental changes of drug disposition during childhood.

Awards & Grants

Awards & Grants

Funding in support of Estimating Renal Function using Cystatin C and Creatinine in the Paediatric Cystic Fibrosis Population – Awarded by Canadina Cystic Fibrosis Foundation

Funding in support of Cardiovascular Function in Obese Children and Adolescent – Awarded by Children’s Health Research Institute

Funding in support of Steroid-induced osteoporosis in the paediatric population – Canadian Incidence Study – Canadian Institutes of Health Research

Funding in support of Cystatin C as a Marker for Detecting Early Renal Dysfunction in a Pediatric Emergency Department – Awarded by The Physicians’ Services Incorporated Foundation

Funding in support of Childhood Obesity – Cross-sectional study on the prevalence of overweight children attending Children’s Hospital, London Health Science Centre – Awarded by Children’s Health Foundation

Recent Publications

Publications

Using individual DSA titers to assess for accommodation after late humoral rejection
Filler G, Grimmer J, Ball E, Sharma AP, Huang SHS
Pediatr Transplant. 2014 June; 18(4): E109-13

Do we need to worrry about myocophenolate overdose?
Filler G, Ferrand AC
Expert Opin Drug Saf. 2014 May; 13(5):521-4

Combined liver kidney transplantation for hyperoxaluria type II?
Filler G, Hoppe B
Pediatr Transplant. 2014 May; 18(3): 237-9

β-trace protein may be a more suitable marker of neonatal renal function
Filler G, Lopes L, Harrold J, Bariciak E
Clin Nephrol. 2014 Apr; 81(4):269-76

Skeletal findings in the first 12 months following initiation of glucocorticoid therapy for pediatric nephrotic syndrome
Phan V, Blydt-Hansen T, Feber J, Alos N, Arora S, Atkinson S, Bell L, Clarson C, Couch R, Cummings E, Filler G, Grant RM, Grimmer J, Hebert D, Lentle B, Matzinger M, Midgley J, Pinsk M, Rodd C, Shenouda N, Stein R, Stephure D, Taback S, Williams K, Rauch F, Siminoski K, Ward LM, and the Canadian STOPP Consortium
Osteoporos Int. 2014 Feb; 25(2):627-37

No association between cyclosporine levels and dyslipidemia?
Filler G
Nephrourol Mon. 2014 Jan 13; 6(1):e14296

Measuring and Linking Physician Productivity to Remuneration: A 3-Year Study in an Academic Medical Department
Filler G, Burkoski V, Tithecott G
Acad Med. 2014 Jan; 89(1):144-52

Diagnosis of Peritoneal Dialysis-Associated Hydrothorax in an Infant with Peritoneal Scintigraphy
Chavannes M, Sharma AP, Singh R, Reid R, Filler G
Perit Dial Int. 2014 Jan; 34(1):140-3

Similar MPA Exposure on Modified Release and Regulat Tacrolimus
Filler G, Vinks AA, Huang SHS, Jevnikar A, Muirhead N
Ther Drug Monit. 2013 Dec 20

Tandem hemodialysis and plasma exchange
Filler G, Clark WF, Huang SHS
Pediatr Nephrol. 2013 Sept 11

Are the children and adolescents with congenital heart disease living in Southwestern Ontario really overweight and obese?
Welisch E, Rauch R, Seabrook JA, Filler MG, Norozi K
Cardiol Young. 2013 Sept 25; 1-6

Trace Elements in Dialysis
Feiller G, Felder S
Pediatr Nephrol. 2013 Aug 16

Skeletal findings in the first 12 months following initiation of glucocorticoid therapy for pediatric nephrotic syndrome
Phan V, Blydt-Hansen T, Feber J, Alos N, Arora S, Atkinson S, Bell L, Clarson C, Couch R, Cummings E, Filler G, Grant RM, Grimmer J, Hebert D, Lentle B, Matzinger M, Midgley J, Pinsk M, Rodd C, Shenouda N, Stein R, Stephure D, Taback S, Williams K, Rauch F, Siminoski K, Ward LM, the Canadian STOPP Consortium
Osteoporos Int. 2013 Aug 16

Social Paediatris: From 'lip service' to the health and well-being of Canada's children and youth
Daneman D, Kellner J, Bernstein M, Dow K, Dugas MA, Duffy C, Eddy A, Filler G, Frappier JY, Gilmour S, Givelichian L, Huang L, Greenberg CR, Shevell M, Vardy C, Walti H, Orrbine E, Williams M
Paediatr Child Health. 2013; 18(7):351-352

Applying the WHO Instead of CDC Growth Charts May Double Obesity Rates
Yasin A, Filler G
Open Journal of Pediatrics. 2013; 3:139-146

Nighttime blood pressure, systolic blood pressure variability, and left ventricular mass index in children with hypertension
Sharma A, Mohammed J, Thomas B, Landsdell N, Norozi K, Filler G
Pediatr Nephrol. 2013 Aug; 28(8):1275-1282

Rising Part-Time Work in the Academic Pediatric Workforce in Canada
Filler G, Givelichian L, Walti H, Piedboeuf B
J Pediatr. 2013 Feb 17; 14:39

Fibroblast growth factor-23 and calcium phosphate product in young chronic kidney disease patients: A cross-sectional study
Liu D, Chau L, Madrenas J, Filler G
BMC Nephrology. 2013 (Feb); 14:39

Adaptation in the First Month of Life
Filler G, Lepage N. Cystatin C
Pediatr Nephrol. 2013 Feb 23

Methods of Assessing Renal Function
Filler G, Yasin A, Medeiros M
Pediatr Nephrol. 2013 Feb 17

Hypertension presenting as facial nerve palsy in children: a case report
Hart LM, McKillop S, Van Hooren TA, Filler G
Journal of Symptoms and Signs. 2013; 2(1): 61-67

Non-invasive measurement of cardiac output in obese children and adolescents: Comparison of Electrical Cardiometry and transthoracic Doppler Echocardiography
Rauch A, Welisch E, Landsdell N, Burrill E, Jones J, Robinson T, Bock D, Clarson C, Filler G, Norozi K
J Clin Monit Comput. 2012 Nov 21

High prevalence of renal dysfunction also after small bowel transplantation
Filler G, Huang SHS
Pediatr Transplant. 2012 May; 16(3):214-6

Ω3 Fatty Acids May Reduce Hyperlipidemia in Pediatric Renal Transplant Recipients
Filler G, Weiglein G, Gharib MT, Casier S
Pediatr Transplant. 2012 Jul 27

Antibody Mediated Rejection Associated With Complement Factor H-Related Protein 3/1 Deficiency Successfully Treated With Eculizumab
Noone D, Al-Matrafi J, Tinckam K, Zipfel PF, Herzenberg AM, Thorner PS, Pluthero FG, Kahr WH, Filler G, Hebert D, Harvey E, Licht C
Am J Transplant. 2012 Jun 8

Unnecessarily Delayed Recognition of Nephrogenic Diabetes Insipidus in an Infant
Paina M, Bichet DG, Gharib MT, Filler G
Journal of Symptoms and Signs. 2012; 1 (2):57-61

Why Multidisciplinary Clinics Should be the Standard for Treating Chronic Kidney Disease?
Filler G, Lipshultz SE
Pediatr Nephrol. 2012 Jul 4

The Usefulness of Cystatin C and Related Formulae in Pediatrics. Clinical Chemistry and Laboratory Medicine. Review.
Filler G, Huang SHS, Yasin A
Clin Chem Lab Med. 2012 Jul 6

Muscle force and power in obese in overweight children
Rauch R, Veilleux LN, Rauch F, Bock D, Welisch E, Filler G, Robinson T, Burrill, E, Norozi, K
J Musculoskelet Neuronal Interact. 2012 Jun; 12(2):80-3

Cystatin C for assessment of GFR in neonates with congenital renal anomalies
Filler G, Grimmer J, Huang SHS, Bariciak E
Nephrol Dial Transplant. 2012 Jun 25

Are Canadian Pediatric Nephrology Patients Really Overweight?
Yasin A, Benidir A, Filler G
Clin Nephrol. 2012 Jun 26

High Prevalence of Elevated Lead Levels in Pediatric Dialysis Patients
Filler G, Yasin A, Roach E, Sharma AP, Blake PG, Yang L
Pediatr Nephrol. 2012 Sep; 27(9):1551-1556

Residual renal function calculated from serum cystatin C measurements and knowledge of the weekly standard kt/v urea
Huang SH, Filler G, Lindsay RM
Perit Dial Int. 2012 Jan; 32(1):102-4

High prevalence of hypertension and renal glomerular and tubular dysfunction after orthotopic liver transplantation
Filler G, Huang SHS
Pediatr Transplant. 2012 May; 16(3):214-6

Ontario Children have Outgrown the Broselow Tape
Milne WK, Yasin A, Knight J, Noel D, Lubell R, Filler G
CJEM. 2012 Jan 1; 14(1):25-30

Are the career choices of pediatric residents meeting the needs of academic centres in Canada?
Piedboeuf B, Jones S, Orrbine E, Filler G
Paediatrics & Child Health. 2012 January; Volume 17 Issue 1:17-20

Are FGF-23 concentrations in renal transplant patients different from non-transplanted CKD patients?
Filler G, Liu D, Sharma AP, Grimmer J
Pediatr Transplant. 2012 Feb; 16(1):73-7

Prevention of Chronic Kidney Disease in Spina Bifida
Filler G, Gharib M, Casier S, Ehrich JHH, Dave S
Int Urol Nephrol. 2012 Jun; 44(3):817-27

A simple formula for estimation of extracellular volume - too simple?
Huang SHS
Clin J Am Soc Nephrol. 2011 Apr; 6(4):65-6

Racial disparities in hemoglobin concentration in children
CKD Filler G, Huang SH, Sharma AP
Am J Kidney Dis. 2010 Jun; 55(6):981-3

Progress in pediatric kidney transplantation
Filler G, Huang SH
Ther Drug Monit. 2010 Jun; 32(3):250-2

Pediatric reference intervals for immunoglobulin G and its subclasses with Siemens immunonephelometric assays
Lepage N, Huang SH, Nieuwenhuys E, Filler G
Clin Biochem. 2010 May; 43(7-8):694-6

Random pharmacokinetic profiles of EC-MPS in children with autoimmune disease
Filler G, Sharma AP, Levy DM, Yasin A
Pediatr Rheumatol Online J. 2010 Jan 4; 8(1):1

Rituximab in refractory nephrotic syndrome
Prytuła A, Iijima K, Kamei K, Geary D, Gottlich E, Majeed A, Taylor M, Marks SD, Tuchman S, Camilla R, Ognjanovic M, Filler G, Smith G, Tullus K
Pediatr Nephrol. 2010 Mar; 25(3):461-8

Relationships among serum iron, inflammation, and body mass index in children
Sharma AP, McKenna AM, Lepage N, Nieuwenhuys E, Filler G
Adv Pediatr. 2009; 56:135-44

Development of a beta-trace protein based formula for estimation of glomerular filtration rate
Benlamri A, Nadarajah R, Yasin A, Lepage N, Sharma AP, Filler G
Pediatr Nephrol. 2010 Mar; 25(3):485-90

Adherence to waiting-time targets for pediatric nephrology clinic referrals
Radina M, Sharma AP, Yasin A, Filler G
Pediatr Nephrol. 2010 Feb; 25(2):311-6

Additional publications

Contact

Contact

Phone: (519) 685-8500, x58377
Fax: (519) 685-8156
Email: guido [dot] filler [at] lhsc [dot] on [dot] ca 
Website(s): https://www.schulich.uwo.ca/paediatrics/faculty/guido-filler
http://www.londonhospitals.ca/departments/medical_affairs/leadership/paediatrics.php

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