Genevieve Eastabrook

Maternal, Fetal & Newborn Health Dr. Genevieve Eastabrook
Associate Scientist
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Affiliations

Associate Scientist, Division of Maternal, Fetal & Newborn Health, Children's Health Research Institute
Assistant Professor, Department of Obstetrics & Gynaecology, Schulich School of Medicine & Dentistry, Western University

How does my research help children?

Placentally-mediated complications of pregnancy, including pre-eclampsia and intrauterine growth restriction, are major contributors to preterm delivery, perinatal mortality, and neonatal morbidity. These pregnancy complications may result in the children being at significant risk of neurodevelopmental, metabolic, and cardiovascular complications later in life.
As maternal obesity is now the most significant risk factor for pre-eclampsia in North America there is need for an understanding of the unique pathophysiology of abnormal placental function and cardiovascular maladaptation to pregnancy in obese women. Our research benefits children by better understanding how to prevent iatrogenic preterm delivery due to maternal illness or fetal growth restriction, and may also give us better insight into childhood obesity and metabolic syndrome as it relates to an adverse in utero environment.

 


Research

Current Research

The Collaborative Obesity in Pregnancy Research Group conducts clinical research focusing on better detection of abnormal placental function, to improve pregnancy outcome, prevent stillbirth and long term consequences of abnormal intrauterine environment, such as childhood obesity and diabetes. Together with our collaborators and co-investigators, we

• Investigate how novel MRI-based technologies can contribute to our understanding and ability to detect abnormal metabolism inside the womb
• Determine how the assessment of cardiovascular health can be clinically useful in the pregnancy of patients with high BMI, using Pulse Wave Velocity (PWV)
• Investigate changes in metabolic and inflammatory markers, decorin levels and placental autophagy in patients with obesity and/or preeclampsia
• Study the effect of maternal obesity, mode of delivery and preventative use of antibiotics for Group B streptococci on the early development of the infant’s microbiota
• Assess women’s and clinicians’ experiences with pregnancy care for patients with obesity, participation in clinical research, prenatal testing and future health of the baby

Research Team
The Collaborative Obesity in Pregnancy Research Group: Supporting a Team to Investigate Placental Adaptations to Obesity has been awarded a Canadian Institutes of Health Research, Institute of Human Development, Child and Youth Health and Society of Obstetricians and Gynaecologists (CIHR/IHDCYH/SOGC) Team Grant, with matching funding from the Children’s Health Research Institute, the Dean's office, Department of Obstetrics and Gynaecology and Women’s Development Council.
Co-investigators:
Dr Genevieve Eastabrook (Co-PI) MD (Assistant Professor, Obstetrics and Gynecology)
Dr Victor Han MD (Professor, Pediatrics)
Dr Peeyush Lala MD PhD (Professor-Emeritus, Anatomy and Cell Biology)
Dr Charles McKenzie PhD (Associate Professor, Medical Biophysics)
Dr Debbie Penava MD (Associate Professor, Obstetrics and Gynecology)
Dr Timothy Regnault PhD (Associate Professor, Obstetrics and Gynecology)
Dr Trevor Shepherd PhD (Assistant Professor, Obstetrics and Gynecology)
Dr Samuel Siu MD (Professor, Medicine/Cardiology)

Collaborators:
Dr Jeremy Burton PhD dBA (Assistant Professor, Surgery)
Dr Marilyn Evans RN PhD (Associate Professor, Associate Professor
Arthur Labatt Family School of Nursing)
Dr Michelle Mottola PhD (Professor, Anatomy and Cell Biology)
Dr Jeff Nisker MD PhD (Professor, Obstetrics and Gynecology)
Dr Bryan Richardson MD (Professor, Physiology/Pharmacology and Pediatrics)
Dr Jamie Seabrook PhD (Assistant Professor, School of Foods and Nutritional Sciences)

Research Assistants:
Jennifer Ryder MHS
Laura McMurphy MSc


Awards & Grants

Grants

CIHR/IHDCYH/SOGC Team Grant: Clinician-Investigator Teams in Obstetrics & Maternal-Fetal Medicine
Children’s Health Research Institute, Translational Research Grant (TRGF)
Western University, Department of Obstetrics and Gynaecology Academic Enrichment Fund

Recent Publications

Publications

Siddiqui MF, Nandi P, Girish GV, Nygard K, Eastabrook G, de Vrijer B, Han VK, Lala PK. Decorin over-expression by decidual cells in preeclampsia: a potential blood biomarker. Am J Obstet Gynecol, 2016 Sep 1; 215 (3): 361.e1-361.e15
Magee LA, Pels A, Helewa M, Rey E, von Dadelszen P, Canadian Hypertensive Disorders of Pregnancy (HDP) Working Group, Canadian Hypertensive Disorders of Pregnancy HDP Working Group. The hypertensive disorders of pregnancy (29.3). Best Pract Res Clin Obstet Gynaecol, 2015 Jul 1; 29 (5): 643-57
Thomson B, Joseph G, Clark WF, Hladunewich M, Patel A, Blake P, Eastabrook G, Matsui D, Sharma A, House A. Maternal, pregnancy and fetal outcomes in de novo anti-glomerular basement membrane antibody disease in pregnancy: a systematic review. Clin Kidney J, 2014 Oct 1; 7 (5): 450-6
Magee LA, Pels A, Helewa M, Rey E, von Dadelszen P, Canadian Hypertensive Disorders of Pregnancy Working Group. Diagnosis, evaluation, and management of the hypertensive disorders of pregnancy: executive summary. J Obstet Gynaecol Can, 2014 May 1; 36 (5): 416-41
Hutcheon JA, Skoll MA, Eastabrook GD, Lim KI. The Case for Universal Cervical Length Screening to Prevent Preterm Birth: Is it Strong Enough to Change Practice in Canada? J Obstet Gynaecol Can, 2012 Dec 1; 34 (12): 1184-7
Hu Y, Yuen R, Eastabrook G, Dutz J, Tan R, von Dadelszen P, Robinson W. PP065. dNK and dNK-CM mediated alterations of DNA methylation in extravillous cytotrophoblasts (EVTS). Pregnancy Hypertens, 2012 Jul 1; 2 (3): 277
Eastabrook GD, Hu Y, Tan R, Dutz JP, Maccalman CD, von Dadelszen P. Decidual NK cell-derived conditioned medium (dNK-CM) mediates VEGF-C secretion in extravillous cytotrophoblasts. Am J Reprod Immunol, 2012 Feb 1; 67 (2): 101-11
Eastabrook G, Brown M, Sargent I. The origins and end-organ consequence of pre-eclampsia. Best Pract Res Clin Obstet Gynaecol, 2011 Aug 1; 25 (4): 435-47
von Dadelszen P, Dwinnell S, Magee LA, Carleton BC, Gruslin A, Lee B, Lim KI, Liston RM, Miller SP, Rurak D, Sherlock RL, Skoll MA, Wareing MM, Baker PN, Research into Advanced Fetal Diagnosis and Therapy (RAFT) Group. Sildenafil citrate therapy for severe early-onset intrauterine growth restriction. BJOG, 2011 Apr 1; 118 (5): 624-8
Hu Y, Eastabrook G, Tan R, MacCalman CD, Dutz JP, von Dadelszen P. Decidual NK cell-derived conditioned medium enhances capillary tube and network organization in an extravillous cytotrophoblast cell line. Placenta, 2010 Mar 1; 31 (3): 213-21
Eastabrook G, Hu Y, von Dadelszen P. The role of decidual natural killer cells in normal placentation and in the pathogenesis of preeclampsia. J Obstet Gynaecol Can, 2008 Jun 1; 30 (6): 467-76
Hu Y, Tan R, MacCalman CD, Eastabrook G, Park SH, Dutz JP, von Dadelszen P. IFN-gamma-mediated extravillous trophoblast outgrowth inhibition in first trimester explant culture: a role for insulin-like growth factors. Mol Hum Reprod, 2008 May 1; 14 (5): 281-9

Contact

Contact

Phone: (519) 685-8500, x66091
Fax: (519) 646-6213
Email: genevieve [dot] eastabrook [at] lhsc [dot] on [dot] ca