Fred Possmayer

Maternal, Fetal & Newborn Health Dr. Fred Possmayer
Associate Scientist
Photo

Affiliations

Associate Scientist, Division of Maternal, Fetal & Newborn Health, Children's Health Research Institute
Professor Emeritus, Departments of Biochemistry and Obstetrics & Gynaecology, Western University

 

Research

Research Focus

Dr. Possmayer developed a technique to purify and sterilize lung surfactant - a substance that allows lungs to expand and breathe.  After saving the lives of countless premature babies with BLES, the surfactant he developed, his work is now focused on adults.  BLES is manufactured in London and used by more than 99 percent of the neonatal intensive care units in Canada.

Recent Publications

Publications

Specific cleavage of the lung surfactant protein A by human cathepsin S may impair its antibacterial properties
Lecaille F, Naudin C, Sage J, Joulin-Giet A, Courty A, Andrault PM, Veldhuizen RA, Possmayer F, Lalmanach G
Int J Biochem Cell Biol. 2013 May 22; 45(8):1701-1709

Adaptation to low body temperature influences pulmonary surfactant composition thereby increasing fluidity while maintaining appropriately ordered membrane structure and surface activity
Suri LN, McCaig L, Picardi MV, Ospina OL, Veldhuizen RA, Staples JF, Possmayer F, Yao LJ, Perez-Gil J, Orgeig S
Biochim Biophys Acta. 2013; 1818(7):1581-1589

The enteric bacterial mebolite proprionic acid alters locomotor activity and brain and plasma phospholipid molecular species: further development of a rodent model of autism spectrum disorder Thomas RH, Meeking MM, Mepham JR, Tichenoff L, Possmayer F, Liu S and MacFabe DF
J Neuroinflammation. 2012; 9:153

A modified squeeze-out mechanism for generating high surface pressures with pulmonary surfactant
Keating E, Zuo YY, Tadayyon SM, Petersen NO, Possmayer F, Veldhuizen RA
Biochim Biophys Acta. 2012; 1818:1225-34

Surfactant protein B inhibits secretory phospholipase A2 hydrolysis of surfactant phospholipids
Hite RD, Grier BL, Waite BM, Veldhuizen RA, Possmayer F, Yao LJ, Seeds MC
Am J Physiol Lung Cell Mol Physiol. 2012; 302(2):L257-65

Retinoic acid is a key regulatory switch determining the difference between lung and thyroid fates in Xenopus laevis
Wang JH, Deimling SJ, D'Alessandro NE, Zhao L, Possmayer F, Drysdale TA
BMC Dev Biol. 2011; 20;11:75

Atomic force microscopy analysis of rat pulmonary surfactant films
Jiao X, Keating E, Tadayyon S, Possmayer F, Zuo YY, Veldhuizen RA
Biophys Chem. 2011; 158:119-25

A TOF-SIMS study of the lateral organization of lipids and proteins in pulmonary surfactant systems
Keating E, Waring AJ, Walther FJ, Possmayer F, Veldhuizen RA, Petersen, NO
Biochim Biophys Acta- Biomembranes. 2011; 1808(3):614-21

Contact

Contact

Phone: (519) 661-2111, x80972
Email: fpossmay [at] uwo [dot] ca