Elizabeth P. Hayden

Children's Health & Therapeutics Dr. Elizabeth P Hayden
Scientist
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Affiliations

Scientist, Division of Children’s Health and Therapeutics, Children’s Health Research Institute
Associate Professor, Department of Psychology, Western University

How my research helps children

In my lab, we are interested in examining linkages between genes, temperament, cognition, and mood disorders within a developmental psychopathology framework. Our research on this issue includes children and adults, as well as clinical and non-clinical samples, with an emphasis on longitudinal designs and multimethod assessment strategies. We strive to take a “top-down” approach to depression vulnerability, incorporating both biological and contextual variables in our projects, and to use developmentally sensitive measures of behavior. Current projects include a SSHRC-funded study of the associations between child emotional behavior and cognitive vulnerability to depression and anxiety, and a study of gene-environment interactions and cortisol reactivity in predicting childhood emotional development (funded by Canadian Institute of Health Research).  The long-term goal of my work is to better identify early-emerging predictors of risk for depression to help inform early prevention and intervention.

Research

Current Research Activities

In my lab, we are interested in examining linkages between genes, temperament, cognition, and mood disorders within a developmental psychopathology framework. Our research on this issue includes children and adults, as well as clinical and non-clinical samples, with an emphasis on longitudinal designs and multimethod assessment strategies. We strive to take a “top-down” approach to depression vulnerability, incorporating both biological and contextual variables in our projects, and to use developmentally sensitive measures of behavior. Current projects include a SSHRC-funded study of the associations between child emotional behavior and cognitive vulnerability to depression and anxiety, and a study of gene-environment interactions and cortisol reactivity in predicting childhood emotional development (funded by Canadian Institute of Health Research)
 

Research Team

Katie Kryski is a second year Ph.D. student in Clinical Psychology. Her research interests include exploring the development of mood disorders in childhood with a gene-environment interactionist perspective and the ability of psychophysiological reactivity and recovery to inform these interactions
 
Heather Smith is a first year Ph.D. student in Clinical Psychology. Her research involves the study of effortful control and emotion regulation and the interplay of these constructs with biological vulnerability to determine later adjustment.

Sarah Mackrell is a first year Ph.D. student in Personality and Measurement. Her research involves the study of temperament and developmental differences in physiological reactivity and recovery.
 
Haroon Sheikh's (a second-year Ph.D. student in Biology) current project is to investigate if the val66met polymorphism of the Brain-Derived Neurotrophic Factor (BDNF) is modulating HPA-axis reactivity in pre-school aged children. His long-term goals include mapping genomic variants that might be involved in cognitive vulnerability during early-development.

Awards & Grants

Awards & Grants

Funding in support of "Quality of Life Initiative" – Awarded by Children's Health Research Institute (CHRI)

Funding in support of "A preliminary investigation of the structural neural correlates of early stress – Awarded by Academic Development Fund (ADF)

Funding in support of “Temperamental Emotionality in Preschoolers and Depression Risk” – Awarded by National Institute of Mental Health, US

Funding in support of “Emerging childhood vulnerability to depression: Biological, emotional, and cognitive pathways” – Awarded by Ontario Ministry of Research and Innovation

Funding in support of “Gene-environment interplay and the developmental psychopathology of internalizing disorders” – Awarded by Canadian Institute of Health Research (CIHR)

Funding in support of “Childhood temperamental vulnerability to internalizing psychopathology: Emotional and cognitive pathways” – Awarded by Social Sciences and Humanities Research Council

Funding in support of “Cognitive vulnerability in adolescents at risk for depression” – Awarded by Ontario Mental Health Foundation

Funding in support of “Molecular genetics of child temperament” – Awarded by National Alliance for Research on Schizophrenia and Affective Disorders (NARSAD), USA

Recent Publications

Publications

Structure of observed temperament in middle childhood
Kotelnikova Y, Olino TM, Mackrell SVM, Jordan PJ, Hayden EP
Journal of Research in Personality. 2013; 47:524-532

Catechol-O-Methyltransferase gene val158met polymorphism and depressive symptoms during early childhood
Sheikh HI, Kryski KR, Smith HJ, Dougherty LR, Bufferd SJ, Klein DN, Singh SM, Hayden EP
American Journal of Medical Genetics: Neuropsychiatric Genetics. 2013; 162B, 245-252

Child dopamine transporter genotype and parenting: Evidence for evocative gene-environment correlations
Hayden EP, Hanna B, Sheikh HI, Laptook RS, Kim J, Singh SM, Klein DN
Development and Psychopathology. 2013; 25:163-173

Corticotropin-releasing hormone system polymorphisms are associated with children's cortisol reactivity
Sheikh HI, Kryski KR, Smith HJ, Hayden EP, Singh SM
Neuroscience. 2013; 229:1-11

Negative life events and cognitive vulnerability to depression: Informant effects and sex differences in the prediction of depressive symptoms in middle childhood
Mackrell SVM, Johnson EM, Dozois DJA, Hayden EP
Personality and Individual Differences. 2013; 54:463-468

Gender differences in young children’s temperament traits: An observational study
Olino TM, Durbin CE, Klein DN, Hayden EP
Journal of Personality. 2012; 81:119-129

Parenting and child DRD4 genotype interact to predict children’s early emerging effortful control
Smith HJU, Sheikh HIU, Dyson MW, Olino TM, Laptook RS, Hayden EP, Singh SM, Klein DN
Child Development. 2012; 83:1932-1934

Additive effects of the dopamine D2 receptor (DRD2) and dopamine transporter (DAT1) gene on the error-related negativity (ERN) in young children
Meyer A, Klein DN, Torpey DC, Kujawa AJ, Hayden EP, Sheikh HI, Singh SM, Hajcak G
Genes, Brain, and Behavior. 2012; 11:695-703

Assessing stress reactivity indexed via salivary cortisol in preschool-aged children
Kryski KR, Smith HJ, Sheikh HI, Singh SM, Hayden EP
Psychoneuroendocrinology. 2011; 36, 1127-1136

Maternal personality influences the relationship between maternal reports and laboratory measures of child temperanent
Hayden EP, Durbin CE, Klein DN, Olino TM
J Personality Assessment. 2010; 92, 586-593

The role of BDNF genotype, parental depression, and relationship discord in predicting early-emerging negative emotionality
Hayden EP, Klein DN, Dougherty LR, Olino TM, Dyson MW, Durbin CE, Sheikh HI, Singh SM
Psychological Science. 2010; 21, 1678-1685

The Dopamine D2 Receptor Gene and depressive and anxious symptoms in childhood: Associations and evidence for gene-environment correlation and gene-environment interaction
Hayden EP, Klein DN, Dougherty LR, Olino TM, Durbin CE, Sheikh HI, Singh SM
Psychiatric Genetics. 2010; 20, 304-310

The serotonin transporter promoter polymorphism and childhood positive and negative emotionality
Hayden EP, Klein DN, Olino TM, Dougherty LR, Durbin CE, Sheikh HI, Singh SM
Emotion. 2010; 10, 696-702

Genotyping the BDNF rs6265 (val66met) polymorphism by one-step Amplified Refractory Mutation System PCR
Sheikh HI, Hayden EP, Kryski KR, Smith HJ, Singh S
Psychiatr Genet. 2010 Jun; 20(3):109-12

Interaction Between 5-HTTLPR and BDNF Val66Met Polymorphisms on HPA Axis Reactivity in Preschoolers
Dougherty LR, Klein DN, Congdon E, Canli T, Hayden EP
Biol Psychol. 2010 Feb; 83(2):93-100

Glucagon-Like Peptide-1 Receptor Gene polymorphism (Leu260Phe) is associated with morning cortisol in preschoolers
Sheikh HI, Dougherty LR, Hayden EP, Klein DN, Singh S
Prog Neuropsychopharmacol Biol Psychiatry. 2010 May 15

Temperamental positive and negative emotionality and children's depressive symptoms: A longitudinal prospective study from age three to age ten
Dougherty LR, Klein DN, Durbin CE, Hayden EP, Olino TM
Journal of Social and Clinical Psychology. 2010; 29:464-490

Additional publications

Contact

Contact

Phone: (519) 661-3686
Fax: (519) 850-2554
Email: ehayden [at] uwo [dot] ca
Website: http://www.ssc.uwo.ca/psychology/faculty/hayden_res.htm

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