Asuri Narayan Prasad

Children's Health & Therapeutics Dr. Asuri Narayan Prasad
Associate Scientist
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Affiliations

Associate Scientist, Division of Children’s Health and Therapeutics, Children’s Health Research Institute
Associate Scientist, Lawson Health Research Institute
Paediatric Neurologist, Paediatric Neurology, Children’s Hospital, London Health Science Centre
Director, Paediatric Epilepsy Monitoring Service, Children’s Hospital, London Health Sciences Centre

How my research helps children

My research involves bridging the knowledge gap between the patient bedside and the lab bench. Perspectives gleaned from clinical observations are critical in the generation of new hypothesis and new directions into research. A major part of my work is directed towards better clinical understanding of rare genetic and metabolic disorders, so that treatment options can be widened.

Research

Current Research Activities

Specific areas of research interest are:
• Epidemiology and natural history of childhood epilepsy
• Organic acidemias, in particular glutaricaciduria; neurochemistry and neuropathological aspects, animal models
• Genetic and neurobiological basis of pervasive developmental disorders
• Genetic basis of epilepsy, metabolic basis of neurological disorders
• Epileptic encephalopathies of infancy and childhood
• Cerebral morphogenesis, developmental controls of brain and craniofacial structure with reference to agenesis of the corpus callosum, neuronal migration defects, and holoprosencephaly

As a research scientist (Associate Scientist at Lawson Health Research Institute and the Child Health Program,) and scholar, Dr. Prasad has made several unique contributions. He has been successfully awarded many grants and research awards. He has over 100 publications (original papers and published abstracts in peer reviewed journals). His papers have been cited in many leading journals in the field of neurosciences and epilepsy. He has presented his work at national and international conferences where he has been an invited speaker. He has served as a peer reviewer for many leading international journals (Epilepsia, Archives of Diseases of Childhood, Epilepsy Research, Developmental Medicine & Child Neurology) and as a member of the Scientific Committee of the American Epilepsy Society.

Research Team

Work in collaboration with Dr. Chitra Prasad, Dr. Victoria Siu, Dr. T Rupar, Dr. M Rieder in the Department of Pediatrics and Dr. N Rajakumar in the Department of Anatomy and Cell Biology

Future Research Plans

Continuing work along themes already established towards understanding of epilepsy and neurological disease in rare genetic and metabolic disorders

Awards & Grants

Awards & Grants

Funding in support of "Southwestern Ontario Regional Comprehensive Epilepsy Service" – Awarded by AMOSO

Funding in support of "Epilepsy and co-morbid disorders in childhood" – Awarded by Ontario Brain Institute (OBI)

Funding in support of "Developing a Web Based teaching tool for Mitochondrial Disorders" – Awarded by private individuals

Funding in support of "Antiepileptic drugs, homocysteine metabolism and genetic and vascular risk factors in childhood epilepsy" – Awarded by Children's Health Research Institute (CHRI)

Funding in support of "The Burden of Chronic Developmental and Neurological Disabilities in Children and Youth: Analysis of the National Longitudinal Survey of Children and Youth (NLSCY)" – Awarded by The University of Western Ontario, Academic Development Fund (ADF) Competition

Recent Publications

Publications

Epilepsy, school readiness in Canadian children: Data from the National Longitudinal Study of Children and Youth (NLSCY)
Prasad C, Corbett BA, Prasad AN
Seizure. 2014 June; 23(6):435-438

MELAS: A Multigenerational Impact of the MTTL1 A3243G MELAS Mutation
Prasad M, Narayan B, Prasad AN, Rupar CA, Levin S, Kronick J, Ramsay D, Tay KY, Prasad C
Can J Neurol Sci. 2014 March; 41(2):210-219

Exome sequencing reveals a homozygous mutation in TWINKLE as the cause of multisystemic failure including renal tubulopathy in three siblings
Prasad C, Melancon SB, Rupar CA, Prasad AN, Nunez LD, Rosenblatt DS, Majewski J
Mol Genet Metab. 2013 Mar

Recurrent encephalopathy: NAGS (N-acetylglutamate synthase) deficiency in adults
Cartagena A, Prasad AN, Rupar CA, Strong M, Tuchman M, Ah Mew N, Prasad C
Can J Neurol Sci. 2013 Jan; 40(1):3-9

Risk factors for nonsyndromic holoprosencephaly: A Manitoba case-control study
Vaz SS, Chodirker B, Prasad C, Seabrook JA, Chudley AE, Prasad AN
Am J Med Genet A. 2012 Apr; 158A(4):751-8

Natural History of Temporal Lobe Epilepsy: Antecedents and Progression
Shukla G, Prasad AN
Epilepsy Research and Treatment. 2012; Vol 2012, Article ID 195073, 8 pages

Methylenetetrahydrofolate reductase (MTHFR) deficiency and infantile epilepsy
Prasad AN, Rupar CA, Prasad C
Brain Dev. 2011 Oct; 33(9):758-69

Prevalence of childhood epilepsy in Canada
Prasad AN, Sang X, Corbett BA, Burneo JG
Can J Neurol Sci. 2011 Sep; 38(5):719-22

Pyruvate dehydrogenase deficiency and epilepsy
Prasad C, Rupar CA, Prasad AN
Brain Dev. 2011 Sep

Menkes disease and infantile epilepsy
Prasad AN, Levin S, Rupar CA, Prasad C
Brain Dev. 2011 Sep

Genetic Evaluation of the Floppy Infant
Prasad AN, Prasad C
Semin Fetal Neonatal Med. 2010 Dec

Predictive value of the lymphocyte toxicity assay in the diagnosis of drug hypersensitivity syndrome
Elzagallaai AA, Jahedmotiagh Z, Del Pozzo-Magana BR, Knowles SR, Prasad AN, Shear NH, Rieder MJ, Koren G
Mol Diagn Ther. 2010 Oct

Early onset epilepsy and inherited metabolic disorders: diagnosis and management
Prasad AN, Hoffmann GF
Can J Neurol Sci. 2010 May;37(3):350-8

Relationship between antiepileptic drugs and biological markers affecting long-term cardiovascular function in children and adolescents
Cheng LS, Prasad AN, Rieder MJ. Can J Clin Pharmacol
2010 Winter;17(1):e5-46

Status epilepticus in the pediatric ICU: state of the art
Prasad AN
Can J Neurol Sci. 2009 Aug;36 Suppl 2:S92-8

Primary disorders of metabolism and disturbed fetal brain development
Prasad AN, Malinger G, Lerman-Sagie T
Clin Perinatol. 2009 Sep;36(3):621-38.

Susceptibility to febrile seizures: more than just a faulty thermostat!
Prasad AN, Seshia SS
Can J Neurol Sci. 2009 Jul;36(4):A-23

Additional publications

Contact

Contact

Phone: (519) 685-8500, x58332
Fax: (519) 685-8350
Email: narayan [dot] prasad [at] lhsc [dot] on [dot] ca
Website: https://www.schulich.uwo.ca/paediatrics/faculty/narayan-prasad

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